Evaluation of nanobubble extravasation and diffusion through a collagen matrix using microfluidics

Evaluating accumulation and retention of nanoparticles within a tumor is a major challenge, especially because tumors are very heterogeneous. Unlike most optical microscopy methods, ultrasound imaging has a wide field of view, high depth of penetration, and can image in real-time. Thus, it is an excellent imaging modality to capture heterogeneity. Optimizing and evaluating nanoparticle capacity for extravasation into and diffusion through an extracellular matrix is essential for successfully translating nanomedicine to the clinic. This project aims to use a microfluidic platform to simplify the complex in vivo environment for the purpose of assessing new techniques for evaluating nanobubble movement through an extracellular matrix. Another branch of this project analyzes the effect of acoustic radiation forces on nanobubble extravasation.

​

For more information about this project contact michaela.cooley@case.edu